Principal Investigator

GRESHAM_2013-1_200w David Gresham, Ph.D.
Assistant Professor of BiologyI am an evolutionary geneticist interested in adaptive evolution, cell growth regulation and mRNA degradation.

Lab Manager

Nathan2014_200w Nathan Brandt
I manage the Gresham lab, ensuring that all our yeast are kept happy and producing data. Besides maintaining a smooth running laboratory, I am also interested in the domestication of yeast, especially in its role as a fermentor.

Faculty Fellows

sam_diazmunoz_crop_200w Sam Diaz-Munoz 
Website
sam.diazmunoz@nyu.edu


I study how sex, social interactions, and ecology shape viral evolution. Viruses frequently infect the same cell, leading to conflicts of interest over cell resources and affecting evolutionary dynamics. My work in the Gresham lab uses high-throughput RNA sequencing techniques to understand how coinfection affects viral fitness and genetic exchange in lab-evolved and wild viruses.

Post-Doctoral Fellows

NIKI_10302015 Rodoniki Athanasiadou, PhD
Niki is using a combination of molecular biology approaches and bioinformatics to investigate how DNA sequence information is regulated at the transcriptional and post-transcriptional level, so that an organism can respond correctly to the environmental cues. Her goal is to understand the regulation of cell growth and differentiation, with applications in both embryology and aging research.She is particularly keen on developing new methodologies, utilizing the high-throughput sequencing Illumina platform to quantify relative transcription factor binding, RNA degradation rates, absolute transcript abundance and polyA-tail lengths, among others.Outside of the laboratory, Niki is an avid science advocate, promoting the understanding of cutting-edge science by everyone.

Doctoral Students

darach_3in_crop_200w Darach Miller
mRNA regulatory dynamics are enabled and constrained by stability in a transcript-species and txtome-wide fashion. I’m trying to figure out if and how accelerated degradation of a group of transcripts is adaptive during a nitrogen-source upshift. To do this, I’ve developed methods to do high-throughput pooled genetic screens on transcript abundance dynamics, via Barseq after FACS after FISH (aka BFF).
SL-headshot-1_crop_200w Stephanie Lauer
I’m primarily interested in adaptive evolution and the molecular mechanisms that underlie genetic variation. I perform experimental evolution in nutrient-limited environments to understand how genetic changes imposed by selection affect fitness. I’m also exploring the dynamics of copy number variation (CNV) by investigating the effects of stress, chromosomal context, and transcriptional activity on the rate of spontaneous CNV formation.
Lab_pic Farah Abdul-Rahman
I am interested in the genetic and mechanistic determinants of mRNA degradation rates and their influence on gene expression. Specifically, I aim to untangle the relationship between mRNA synthesis and mRNA degradation and its role in mediating differential expression.
IMG_0882 Siyu Sun
I am interested in understanding the conserved mechanisms that regulating cellular quiescence in eukaryotes. My goal is to define the role of each gene in quiescence initiated by carbon, nitrogen or phosphate starvation with high-throughput sequencing (BAR-Seq), and elucidate the dynamics of translational regulation in different nutrient-limiting conditions induced quiescence by ribosome profiling (Ribo-Seq).

Masters Students

IMG_7205 Gunjan Janak Sethia
I am interested in analyzing genome structure, function and evolution using bioinformatics tools and computational methods. Currently, I am working on resolving detection of breakpoints and characterization of structural variants (dealing with the read depth and abnormal positioning of mapped reads) in experimentally evolved yeast strains using computational methods and software(s).

Undergraduate Students

IMG_3209 Saroj Gourkanti
I am interested in studying the signal transduction pathways that surrounds the production of specific proteins and the manipulation of their corresponding genes to affect their production. I am currently studying the generation of extrachromosomal DNA in the yeast genome in nutrient-rich environments using genetically altered plasmids and studying the growth in population of the transformed yeast.
Alexander Ferrena
My interest lies in studying the evolution and structure of the genome as well as its function in terms of expression. I aim to do this using quantitative and computational methods. I am currently investigating RNA-seq data using a bioinformatics pipeline in order to determine differential expression of yeast in diverse conditions.

High School Students

CGSB Pic Stephen Nyarko
I’m interested in the molecular pathway responsible for the change in stress resistance of yeast due to alterations of their environment. I’m a junior at Stuyvesant High School and am working to complete a research paper to be submitted to the Intel Science Talent Search Competition.

Alumni

Benjamin Samuel Neymotin (Graduate Student, 2010-2015)
Naomi Ziv (Graduate Student, 2010-2015)
Jungeui Hong (Graduate Student, 2010-2015)
Tayebeh Bahmani (Masters Student, 2009-2011)
Russell Durrett (Undergraduate Student, NYU iGEM team leader, 2010)
Bentley Shuster (Undergraduate Student, 2012)
Alicia Mastrocco (Undergraduate Student, 2011-2012)
Victoria Ettore (Undergraduate Student, 2012-2014)
Sarah Choski (Undergraduate Student, 2013-2014)
Christina Nunez (Undergraduate Student)
Lev Omelchenko (High School Student, 2010)
Anise Rau (High School Student, 2013-2015)
Wei Hou Wu (High School Student, 2013-2015)